The most famous mural in the world is painted on the wall of the Cenacolo Vinciano, or refectory, of the Chiesa di Santa Maria delle Grazie Leonardo Da Vinci's second most famous work after the Mona Lisa is a portrayal of the moment when Jesus announces to his disciples that one of them will betray him. Leonardo made an unfortunate decision to paint it using a tempera mix of oil and egg whites instead of the more durable fresco method as the colours were then more likely to disintegrate over time. The mural has had a tumultuous history over the centuries with various restorations , renovations and was almost lost completely by 19th C restorers using alcohol and cotton wool. Subsequent floods, wars and DIY Dominicans all took their toll leaving the mural almost unrecognisable but the latest project, starting in 1977, was completed in 1999. You must book your ticket in advance over the phone, at least 3-4 days. You are then given a time to turn up and collect your ticket from the refectory desk, about 15mins before your allotted visit. It is advisable not to turn up late as your ticket will be resold. Audioguides and a short tour are available but must be booked also.€1.50 booking fee, admission €6.50